AUTHOR=Huang Jingxuan , Deng Aiping , Bai Yunshuang , Li Chunyu , Shang Huifang 

TITLE=Alzheimer’s disease and oral manifestations: a bi-directional Mendelian randomization study

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1391625

DOI=10.3389/fneur.2024.1391625

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Background</title><p>Epidemiological studies have provided evidence suggesting an association between Alzheimer’s disease (AD) and various oral manifestations. However, conflicting conclusions have been drawn, and whether a causal association truly exists remains unclear.</p></sec><sec id="sec2"><title>Methods</title><p>In order to investigate the potential causal association between AD and prevalent oral diseases, we conducted a bi-directional two-sample Mendelian randomization analysis based on summary statistics from genome-wide association studies of AD (<italic>N</italic> = 63,926), as well as mouth ulcer (<italic>N</italic> = 461,103), oral cavity cancer (<italic>N</italic> = 4,151), and periodontal disease (<italic>N</italic> = 527,652).</p></sec><sec id="sec3"><title>Results</title><p>We identified that one standard increase in the risk of AD was causally associated with a reduced risk of oral cavity cancer (OR = 0.76, 95% CI: 0.63–0.92, <italic>p</italic> = 3.73 × 10<sup>−3</sup>). In the opposite direction, oral conditions were not causally associated with risk of AD.</p></sec><sec id="sec4"><title>Conclusion</title><p>The present findings contributed to a better understanding of the correlation between AD and oral conditions, specifically oral cavity cancer. These results also identified new avenues for exploring the underlying mechanisms of oral cavity cancer.</p></sec>