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REVIEW article

Front. Neurol.
Sec. Experimental Therapeutics
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1389703
This article is part of the Research Topic Review of Hyperbaric Therapy & Hyperbaric Oxygen Therapy in the Treatment of Neurological Disorders According to Dose of Pressure and Hyperoxia View all 13 articles

NEW PERSPECTIVES OF THE USE OF HYPERBARIC OXYGENATION IN THE MANAGEMENT OF ACUTE ISCHEMIC HYPOXIC ENCEPHALOPATHY OF THE NEWBORN: A REVIEW

Provisionally accepted
Ernesto C. Sanchez Rodriguez Ernesto C. Sanchez Rodriguez 1,2,3*Vasthi J. López Vasthi J. López 4
  • 1 National Autonomous University of Mexico, México City, Mexico
  • 2 Michigan State University, East Lansing, Michigan, United States
  • 3 SSY, Merida, Mexico
  • 4 UCN, Coquimbo, Chile

The final, formatted version of the article will be published soon.

    The morbidity and mortality of acute ischemic hypoxic encephalopathy of the newborns have not been dramatically modified in the last 20 years. The review has the purpose to describe the use of hyperbaric oxygenation (HBOT) in the management of acute ischemic hypoxic encephalopathy of the newborn.Review of the medical literature of the use of HBOT in the pathophysiology of this condition and how it modifies the result of the patients treated in an early stage.When HBO2 is administered in a timely and prompt manner, it can promote the survival of the penumbra, modulate the cytokine storm, modify the inflammatory cascades, restore mitochondrial function, inhibit apoptosis, reinstate cellular communication and cytoskeleton function, reinstall the functioning of the kinase system, reduce the cytotoxic and tissue edema, promotes the microcirculation, and promote an antioxidant effect. All these secondary mechanisms help to save, rescue, and protect the marginal tissue.When use promptly, HBOT is a noninvasive adjunct treatment that can preserve the marginal tissue caused by ischemia, hypoxia, maintain the metabolic needs of the penumbra, reduce the inflammatory cascades, avoid extension of the damage tissue, and modulate the ischemia reperfusion injury.

    Keywords: Acute ischemic hypoxic encephalopathy, Hyperbaric Oxygenation therapy, Mitochondria, ischemia reperfusion injury, antioxidant effect

    Received: 22 Feb 2024; Accepted: 24 Jun 2024.

    Copyright: © 2024 Sanchez Rodriguez and López. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ernesto C. Sanchez Rodriguez, National Autonomous University of Mexico, México City, Mexico

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.