AUTHOR=Zhang Kangjia , Zhang Yong , Wu Weijing , Lai Ruosha 

TITLE=Mendelian randomization analysis does not reveal a causal association between migraine and Meniere’s disease

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1367428

DOI=10.3389/fneur.2024.1367428

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Background</title><p>According to observational research, migraine may increase the risk of Meniere’s disease (MD). The two have not, however, been proven to be causally related.</p></sec><sec id="sec2"><title>Methods</title><p>Using Mendelian random (MR) analysis, we aimed to evaluate any potential causal relationship between migraine and MD. We extracted single-nucleotide polymorphisms (SNPs) from large-scale genome-wide association studies (GWAS) involving European individuals, focusing on migraine and MD. The main technique used to evaluate effect estimates was inverse-variance weighting (IVW). To assess heterogeneity and pleiotropy, sensitivity analyses were carried out using weighted median, MR-Egger, simple mode, weighted mode, and MR-PRESSO.</p></sec><sec id="sec3"><title>Results</title><p>There was no discernible causative link between genetic vulnerability to MD and migraine. The migraine dose not increase the prevalence of MD in the random-effects IVW method (OR = 0.551, <italic>P</italic> = 0.825). The extra weighted median analysis (OR = 0.674, <italic>P</italic> = 0.909), MR-Egger (OR = 0.068, <italic>P</italic> = 0.806), Simple mode (OR = 0.170, <italic>P</italic> = 0.737), and Weighted mode (OR = 0.219, <italic>P</italic>= 0.760) all showed largely consistent results. The MD dose not increase the prevalence of migraine in the random-effects IVW method (OR = 0.999, <italic>P</italic> = 0.020). The extra weighted median analysis (OR = 0.999, <italic>P</italic> = 0.909), MR-Egger (OR = 0.999, <italic>P</italic> = 0.806), Simple mode (OR = 0.999, <italic>P</italic> = 0.737), and Weighted mode (OR = 1.000, <italic>P</italic> = 0.760).</p></sec><sec id="sec4"><title>Conclusion and significance</title><p>This Mendelian randomization study provides casual evidence that migraine is not a risk factor for MD and MD is also not a risk factor for migraine.</p></sec>