AUTHOR=Li Zijian , Wang Fuli , He Zhidong , Guo Qi , Zhang Jinnan , Liu Songyan 

TITLE=RELN gene-related drug-resistant epilepsy with periventricular nodular heterotopia treated with radiofrequency thermocoagulation: a case report

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1366776

DOI=10.3389/fneur.2024.1366776

ISSN=1664-2295

ABSTRACT=<p>An increasing number of gene mutations associated with epilepsy have been identified, some linked to gray matter heterotopia—a common cause of drug-resistant epilepsy. Current research suggests that gene mutation-associated epilepsy should not be considered a contraindication for surgery in epilepsy patients. At present, stereoelectroencephalography-guided radiofrequency thermocoagulation is an important method to treat periventricular nodular heterotopia-associated drug-resistant epilepsy. We present a case of drug-resistant epilepsy, accompanied by periventricular nodular heterotopia and a heterozygous mutation of the <italic>RELN</italic> gene, successfully treated with radiofrequency thermocoagulation, resulting in a favorable outcome.</p>