AUTHOR=Cheung Teris , Yee Benjamin K. , Chau Bolton , Lam Joyce Yuen Ting , Fong Kwan Hin , Lo Herman , Li Tim Man Ho , Li Albert Martin , Sun Lei , Beisteiner Roland , Cheng Calvin Pak Wing 

TITLE=Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1364270

DOI=10.3389/fneur.2024.1364270

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Background</title><p>This is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong.</p></sec><sec id="sec2"><title>Methods</title><p>This double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data.</p></sec><sec id="sec3"><title>Results</title><p>The TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups.</p></sec><sec id="sec89"><title>Conclusion</title><p>TPS is an effective and safe adjunct treatment for the clinical management of ADHD.</p></sec><sec id="sec4"><title>Clinical trial registration</title><p><ext-link xlink:href="http://clinicaltrials.gov" ext-link-type="uri" xmlns:xlink="http://www.w3.org/1999/xlink">ClinicalTrials.Gov</ext-link>, identifier NCT05422274.</p></sec>