AUTHOR=Zhou Yi , Jin Xiaomei , Liu Xiaorong , Tang Jiafan , Song Liyan , Zhu Yu , Zhai Wanqing , Wang Xianhui 

TITLE=Correlation between obstructive sleep apnea and hypoperfusion in patients with acute cerebral infarction

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1363053

DOI=10.3389/fneur.2024.1363053

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Purpose</title><p>To explore the relationship between obstructive sleep apnea (OSA) and hypoperfusion during ultra-early acute cerebral infarction.</p></sec><sec id="sec2"><title>Patients and methods</title><p>Data were retrospectively collected from patients admitted to our hospital with acute cerebral infarction between January 2020 and January 2022, who underwent comprehensive whole-brain computed tomography perfusion imaging and angiography examinations within 6 h of onset. The F-stroke software automatically assessed and obtained relevant data (Tmax). The patients underwent an initial screening for sleep apnea. Based on their Apnea-Hypopnea Index (AHI), patients were categorized into an AHI ≤15 (<italic>n</italic> = 22) or AHI &gt;15 (<italic>n</italic> = 25) group. The pairwise difference of the time-to-maximum of the residue function (Tmax) &gt; 6 s volume was compared, and the correlation between AHI, mean pulse oxygen saturation (SpO2), oxygen desaturation index (ODI), percentage of time with oxygen saturation &lt; 90% (T90%), and the Tmax &gt;6 s volume was analyzed.</p></sec><sec id="sec3"><title>Results</title><p>The Tmax &gt;6 s volume in the AHI &gt; 15 group was significantly larger than that in the AHI ≤ 15 group [109 (62–157) vs. 59 (21–106) mL, <italic>p</italic> = 0.013]. Spearman’s correlation analysis revealed Tmax &gt;6 s volume was significantly correlated with AHI, mean SpO2, ODI, and T90% in the AHI &gt; 15 group, however, no significant correlations were observed in the AHI ≤ 15 group. Controlling for the site of occlusion and Multiphase CT angiography (mCTA) score, AHI (β = 0.919, <italic>p</italic> &lt; 0.001), mean SpO2 (β = −0.460, <italic>p</italic> = 0.031), ODI (β = 0.467, <italic>p</italic> = 0.032), and T90% (β =0.478, <italic>p</italic> = 0.026) remained associated with early hypoperfusion in the AHI &gt; 15 group.</p></sec><sec id="sec4"><title>Conclusion</title><p>In patients with acute cerebral infarction and AHI &gt; 15, AHI, mean SpO2, ODI and T90% were associated with early hypoperfusion. However, no such relationship exists among patients with AHI ≤ 15.</p></sec>