AUTHOR=Kamo Hikaru , Oyama Genko , Yamasaki Yui , Nagayama Tomohiro , Nawashiro Ryotatsu , Hattori Nobutaka 

TITLE=A proof of concept: digital diary using 24-hour monitoring using wearable device for patients with Parkinson’s disease in nursing homes

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1356042

DOI=10.3389/fneur.2024.1356042

ISSN=1664-2295

ABSTRACT=<sec><title>Introduction</title><p>In the advanced stages of Parkinson’s disease (PD), motor complications such as wearing-off and dyskinesia are problematic and vary daily. These symptoms need to be monitored precisely to provide adequate care for patients with advanced PD.</p></sec><sec><title>Methods</title><p>This study used wearable devices to explore biomarkers for motor complications by measuring multiple biomarkers in patients with PD residing in facilities and combining them with lifestyle and clinical assessments. Data on the pulse rate and activity index (metabolic equivalents) were collected from 12 patients over 30 days.</p></sec><sec><title>Results</title><p>The pulse rate and activity index during the <italic>off-</italic> and <italic>on-</italic>periods and <italic>dyskinesia</italic> were analyzed for two participants; the pulse rate and activity index did not show any particular trend in each participant; however, the pulse rate/activity index was significantly greater in the <italic>off</italic>-state compared to that in the <italic>dyskinesia</italic> and <italic>on</italic>-states, and this index in the <italic>dyskinesia</italic> state was significantly greater than that in the <italic>on</italic>-state in both participants.</p></sec><sec><title>Conclusion</title><p>These results suggest the pulse rate and activity index combination would be a useful indicator of wearing-off and dyskinesia and that biometric information from wearable devices may function as a digital diary. Accumulating more cases and collecting additional data are necessary to verify our findings.</p></sec>