AUTHOR=Du Yaming , Wang Rui , Xu Xinzi , Wang Junli , Shao Wei , Chen Guohua 

TITLE=Causality between major depressive disorder and functional dyspepsia: a two-sample Mendelian randomization study

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1338153

DOI=10.3389/fneur.2024.1338153

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Background</title><p>To investigate the causal relationship between major depression and functional dyspepsia using two-sample Mendelian randomization.</p></sec><sec id="sec2"><title>Methods</title><p>Data for major depression and functional dyspepsia were obtained from genome-wide association studies. We selected Single Nucleotide Polymorphisms (SNPs) strongly associated with severe depression. Mendelian randomization analysis was conducted using methods such as Inverse-Variance Weighted (IVW), MR-Egger, and Weighted Median Estimator (WME). Sensitivity analysis was performed to assess the robustness of the results.</p></sec><sec id="sec3"><title>Results</title><p>A total of 31 eligible SNPs were identified as instrumental variables for major depression. IVW analysis indicated a positive causal relationship between the two conditions (<italic>β</italic> = 0.328; SE = 0.137; <italic>p</italic> = 0.017), suggesting that severe depression increases the risk of functional dyspepsia (OR = 1.389; 95% CI: 1.062–1.816). Sensitivity tests showed no evidence of heterogeneity or horizontal pleiotropy (<italic>p</italic> &gt; 0.05).</p></sec><sec id="sec4"><title>Conclusion</title><p>MR analysis had shown that major depressive disorder is associated with an increased risk of functional dyspepsia.</p></sec>