AUTHOR=Yang Xia , Liu Qiong , Lai Ming-feng , Ma Xiao-hong , Hao Xiao-ting , Xu Jia-jun , Guo Wan-jun 

TITLE=Case report: Orthostatic leg tremor as the initial manifestation in a patient with metabotropic glutamate receptor-5 encephalitis without cortical dysfunction: complexities in identification and treatment

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1288075

DOI=10.3389/fneur.2023.1288075

ISSN=1664-2295

ABSTRACT=<sec><title>Objective</title><p>Metabotropic glutamate receptor 5 (mGluR5) encephalitis is such a rare type of autoimmune encephalitis that its diagnosis remains a challenge.</p></sec><sec><title>Case report</title><p>A 19-year-old female patient initially presented with anxiety and orthostatic leg tremors without cortical dysfunction. We found that this patient was positive for mGluR5 antibodies in both serum (1:1,000) and cerebrospinal fluid (1:32). After comprehensive intervention, the patient showed complete recovery at the 18-month follow-up.</p></sec><sec><title>Discussion</title><p>This report expands our knowledge of the possible presentations of mGluR5 encephalitis for early diagnosis, which makes it possible to prevent serious consequences and improve the prognosis.</p></sec>