AUTHOR=Li Lei , Lv Jin , Han Jian-jia , Gao Yuan , Yan Zhao-xuan , Wu Qi , Zhang Xiao-li , Gao Feng 

TITLE=Nomogram model of functional outcome for endovascular treatment in patients with acute basilar artery occlusion

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1277189

DOI=10.3389/fneur.2023.1277189

ISSN=1664-2295

ABSTRACT=<sec><title>Background and purpose</title><p>The efficacy and safety of endovascular treatment (EVT) in acute basilar artery occlusion (ABAO) has been confirmed by four randomized clinical trials. Nevertheless, the predictors of a 90-day favorable outcome after EVT have not been elucidated. We attempted to establish a nomogram for the prediction of a 90-day favorable outcome in ABAO patients with EVT.</p></sec><sec><title>Methods</title><p>Clinical data of ABAO patients with EVT were obtained from two nationwide clinical trial registries in China. Factors associated with a 90-day favorable outcome were screened by multivariable step-wise regression on the basis of univariable analysis. A nomogram was established to predict 90-day favorable outcome after EVT.</p></sec><sec><title>Results</title><p>The proportion of ABAO patients with a favorable outcome was 41.53% (157/378). Seven variables, including baseline National Institutes of Health Stroke Scale (NIHSS) &lt;20 [odds ratio (OR): 8.330; <italic>P</italic>-value &lt; 0.0001], posterior circulation Alberta Stroke Program Early CT (pc-ASPECT) score ≥7 (OR: 1.948; <italic>P</italic>-value = 0.0296), Pons-Midbrain Index (PMI) score &lt; 2 (OR: 2.108; <italic>P</italic>-value = 0.0128), Posterior Circulation Collateral Score (PC-CS) ≥5 (OR: 3.288; <italic>P</italic>-value &lt; 0.0001), local anesthesia (OR: 0.389; <italic>P</italic>-value = 0.0017), time from onset to recanalization (OTR) &lt;330 min (OR: 2.594; <italic>P</italic>-value = 0.0013), and no occurrence of early neurological deterioration (END; OR: 0.039; <italic>P</italic>-value &lt; 0.0001) were included into the nomogram, with C-index values of 0.8730 and 0.8857 in the training and the internal validation set, respectively.</p></sec><sec><title>Conclusions</title><p>The proposed nomogram provided a reliable prognostic scale, which can be employed in clinical settings for the selection and clinical management of ABAO patients.</p></sec><sec><title>Registration</title><p><ext-link ext-link-type="uri" xlink:href="https://www.clinicaltrials.gov" xmlns:xlink="http://www.w3.org/1999/xlink">https://www.clinicaltrials.gov</ext-link>, identifier: NCT03370939.</p></sec>