AUTHOR=Hu Yan , Zhang Mingchu , Duan Chengcheng , Song Dengpan , Wei Mingkun , Guo Fuyou 

TITLE=A long-term follow-up study of adults with Chiari malformation type I combined with syringomyelia

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1274971

DOI=10.3389/fneur.2023.1274971

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Background</title><p>There is a considerable amount of controversy regarding the treatment and prognosis of adult patients with Chiari malformation type I (CM-I) at home and abroad; furthermore, no large-sample, long-term, follow-up studies have examined CM-I patients with syringomyelia (SM) comparing posterior fossa decompression with resection of tonsils (PFDRT) vs. posterior fossa decompression with duraplasty (PFDD).</p></sec><sec id="sec2"><title>Objective</title><p>This study retrospectively analyzed the factors affecting the treatment and long-term prognosis of adults with CM-I combined with SM.</p></sec><sec id="sec3"><title>Methods</title><p>We retrospectively analyzed data from 158 adult CM-I patients combined with SM who underwent PFDRT or PFDD, including 68 patients in group PFDRT and 90 patients in group PFDD. We examined the clinical manifestations, imaging features, and follow-up data of patients. Clinical outcomes were assessed using the Chicago Chiari Outcomes Scale (CCOS), and radiographic outcomes were indicated by the syrinx remission rate. Multivariate logistic regression analysis and multiple linear regression analysis were used to explore the relevant factors affecting the long-term prognosis of patients.</p></sec><sec id="sec4"><title>Results</title><p>This study showed that compared with preoperative patients in the PFDRT group and PFDD group, the sensory impairment, cough-related headache, and movement disorder were significantly improved (<italic>p</italic> &lt; 0.01); meanwhile, the diameter of the syrinx and the volume of the syrinx decreased significantly (<italic>p</italic> &lt; 0.001). Additionally, the study found that there were significant differences in the syrinx remission rate (<italic>p</italic> = 0.032) and the clinical cure rates (<italic>p</italic> = 0.003) between the two groups. Multivariate logistic regression analysis showed that age (<italic>p</italic> = 0.021), cerebellar-related symptoms (<italic>p</italic> = 0.044), preoperative cisterna magna volume (<italic>p</italic> = 0.043), and peak systolic velocity (<italic>p</italic> = 0.036) were independent factors for clinical outcomes. Multiple linear regression analysis showed that different surgical procedures were positively correlated with the syrinx remission rate (<italic>p</italic> = 0.014), while preoperative syrinx diameter (<italic>p</italic> = 0.018) and age (<italic>p</italic> = 0.002) were negatively correlated with the syrinx remission rate.</p></sec><sec id="sec5"><title>Conclusion</title><p>In conclusion, this study suggested that, in a long-term follow-up, although both surgical procedures are effective in treating patients with CM-I and SM, PFDRT is better than PFDD; age and cerebellar-related signs independently affect the patient’s prognosis. Additionally, an effective prognosis evaluation index can be developed for patients, which is based on imaging characteristics, such as preoperative cisterna magna volume, preoperative syrinx diameter, and preoperative cerebrospinal fluid (CSF) hydrodynamic parameters to guide clinical work.</p></sec>