AUTHOR=Yong Christl S. K. , Maniam Ethan Jian-Hui , Chang Cheryl W. L. , Lai Jonathan Yexian , Ho Cyrus Su Hui 

TITLE=Case report: Creutzfeldt-Jakob disease presenting with anxiety symptoms in a COVID-19 post-infection patient

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1239576

DOI=10.3389/fneur.2023.1239576

ISSN=1664-2295

ABSTRACT=<p>Creutzfeldt-Jakob Disease (CJD) is a rare, rapidly progressive, and fatal neurodegenerative disorder. We describe a man whose initial manifestations of CJD occurred shortly after contracting Coronavirus disease 2019 (COVID-19). He first developed anxiety and short-term memory loss a few weeks after a mild COVID-19 infection. He subsequently developed parkinsonism, eventually progressed to akinetic mutism, and passed away 5 months after symptom onset. This case highlights a potential temporal relationship between COVID-19 infection and the onset of neurodegenerative symptoms. Microglia and astrocytes in the central nervous system (CNS) and ‘S1’ spike proteins on SARS-CoV-2 are potential mediators in neuroinflammation and neurodegeneration.</p>