AUTHOR=Curiel Cid Rosie E. , Ortega Alexandra , Crocco Elizabeth A. , Hincapie Diana , McFarland Karen N. , Duara Ranjan , Vaillancourt David , DeKosky Steven T. , Smith Glenn , Sfakianaki Efrosyni , Rosselli Monica , Barker Warren W. , Adjouadi Malek , Barreto Yarlenis , Feito Yuleidys , Loewenstein David A.
TITLE=Semantic intrusion errors are associated with plasma Ptau-181 among persons with amnestic mild cognitive impairment who are amyloid positive
JOURNAL=Frontiers in Neurology
VOLUME=14
YEAR=2023
URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1179205
DOI=10.3389/fneur.2023.1179205
ISSN=1664-2295
ABSTRACT=IntroductionSemantic intrusion errors (SI) have distinguished between those with amnestic Mild Cognitive Impairment (aMCI) who are amyloid positive (A+) versus negative (A−) on positron emission tomography (PET).
MethodThis study examines the association between SI and plasma – based biomarkers. One hundred and twenty-eight participants received SiMoA derived measures of plasma pTau-181, ratio of two amyloid-β peptide fragments (Aβ42/Aβ40), Neurofilament Light protein (NfL), Glial Fibrillary Acidic Protein (GFAP), ApoE genotyping, and amyloid PET imaging.
ResultsThe aMCI A+ (n = 42) group had a higher percentage of ApoE ɛ4 carriers, and greater levels of pTau-181 and SI, than Cognitively Unimpaired (CU) A− participants (n = 25). CU controls did not differ from aMCI A− (n = 61) on plasma biomarkers or ApoE genotype. Logistic regression indicated that ApoE ɛ4 positivity, pTau-181, and SI were independent differentiating predictors (Correct classification = 82.0%; Sensitivity = 71.4%; Specificity = 90.2%) in identifying A+ from A− aMCI cases.
DiscussionA combination of plasma biomarkers, ApoE positivity and SI had high specificity in identifying A+ from A− aMCI cases.