AUTHOR=Geng Yibo , Jia Jianwen , Liu Xiaoli , Li Tong , Liu He , Sun Yongquan , Wang Yang 

TITLE=Clinical outcome and prognostic factors of patients with non-traumatic angiography-negative subarachnoid hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1157845

DOI=10.3389/fneur.2023.1157845

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Purpose</title><p>The cause of spontaneous subarachnoid hemorrhage (SAH) is unknown in 10% of cases. The aim of this study was to demonstrate the characteristics of patients with angiography-negative subarachnoid hemorrhage (anSAH) and to analyze factors influencing the clinical outcome in patients suffering from anSAH.</p></sec><sec id="sec2"><title>Methods</title><p>A retrospective cohort of 75 patients with anSAH [26 perimesencephalic (pmSAH) and 49 non-perimesencephalic SAH (npmSAH)] admitted between January 2016 and June 2022 was included. We analyzed demographic, clinical data and 6-month functional outcomes. Enter regression analysis was performed to identify factors associated with outcomes.</p></sec><sec id="sec3"><title>Results</title><p>Unfavorable outcome was achieved in 10 of 75 patients (13.3%). Unfavorable outcome was associated with senior adults (<italic>p</italic> = 0.008), Hijdra cistern score (HCS) elevation (<italic>p</italic> = 0.015), long-time lumbar cistern continuous drainage (LCFD; <italic>p</italic> = 0.029) and hydrocephalus (<italic>p</italic> = 0.046). The only significant risk factor for unfavorable outcome after npmSAH was the HCS (<italic>OR</italic> 1.213 (95%CI 1.007–1.462), <italic>p</italic> = 0.042).</p></sec><sec id="sec4"><title>Conclusion</title><p>Our study provides valuable information on both SAH patterns and functional outcome in patients suffering from anSAH and should be taken into consideration during management of these patients.</p></sec>