AUTHOR=Li Hong-xing , Dong Mei , Peng Xiao-xiao , Liu Yi-zhe , Wang Han , Li Chao , Du Yi-yi , Zhang Kai , Zong Qiang TITLE=A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China JOURNAL=Frontiers in Neurology VOLUME=14 YEAR=2023 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1103164 DOI=10.3389/fneur.2023.1103164 ISSN=1664-2295 ABSTRACT=Background

Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (PRKN) mutations.

Case

In this study, we report the case of a 30-year-old Chinese woman who was affected by PRKN-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.

Conclusion

This case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of PRKN-associated YOPD.