AUTHOR=Li Hong-xing , Dong Mei , Peng Xiao-xiao , Liu Yi-zhe , Wang Han , Li Chao , Du Yi-yi , Zhang Kai , Zong Qiang 

TITLE=A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China

JOURNAL=Frontiers in Neurology

VOLUME=14

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2023.1103164

DOI=10.3389/fneur.2023.1103164

ISSN=1664-2295

ABSTRACT=<sec><title>Background</title><p>Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (<italic>PRKN</italic>) mutations.</p></sec><sec><title>Case</title><p>In this study, we report the case of a 30-year-old Chinese woman who was affected by <italic>PRKN</italic>-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery.</p></sec><sec><title>Conclusion</title><p>This case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of <italic>PRKN</italic>-associated YOPD.</p></sec>