AUTHOR=Xiaoxi Zhang , Xuan Zhu , Lei Zhang , Zifu Li , Pengfei Xing , Hongjian Shen , Yongxin Zhang , Weilong Hua , Yihan Zhou , Dongwei Dai , Qiang Li , Rui Zhao , Qinghai Huang , Yi Xu , Song Lili , Anderson Craig S. , Jianmin Liu , Yongwei Zhang , Pengfei Yang TITLE=Baseline blood pressure does not modify the effect of intravenous thrombolysis in successfully revascularized patients JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.984599 DOI=10.3389/fneur.2022.984599 ISSN=1664-2295 ABSTRACT=Background

Studies indicate a trajectory relationship between baseline blood pressure (BP) and outcome in patients with acute ischemic stroke (AIS) eligible for both intravenous thrombolysis (IVT) with alteplase and endovascular treatment (EVT). We determined whether baseline BP modified the effect of IVT in successfully revascularized AIS patients who participated in the Direct Intra-Arterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals (DIECT-MT) trial.

Methods

The association of baseline systolic BP, trichotomized as high (141–185 mmHg), middle (121–140 mmHg), and low (91–120 mmHg), and the outcomes of any intracerebral hemorrhage (ICH), symptomatic ICH (sICH), and mortality and functional outcome on the modified Rankin scale at 90 days were explored. Logistic regression models determined the interaction between clinical outcomes and baseline systolic and diastolic BP, and mean arterial pressure (MAP), at 10 mmHg intervals. Data are reported as odds ratios (OR) and 95% CI.

Results

A post-hoc analysis of DIRECT-MT, in 510 of the 656 randomized participants with successful revascularization underwent MT. The overall adjusted common OR of IVT and baseline BP on any ICH, sICH, and 90-day mortality and functional outcome were 0.884 (95%CI 0.613–1.274), 0.643 (95%CI 0.283–1.458), 0.842 (95%CI 0.566–1.252), and 1.286 (95%CI 0.772–2.142), respectively. No significant interaction between baseline blood pressure and intravenous thrombolysis with clinical outcome was observed.

Conclusions

In patients with baseline SBP under 185 mmHg, baseline blood pressure does not alter the risk of hemorrhagic transformation and clinical

outcome in successfully revascularized patients, regardless of intravenous alteplase usage. Future studies are needed to confirm our findings.

Registration

URL: http://www.clinicaltrials.gov, Identifier: NCT03469206.