AUTHOR=Zhuo Xiaohuang , Zhou Yongzhao , Liu Ling 

TITLE=Acute bacterial encephalitis complicated with recurrent nasopharyngeal carcinoma associated with Elizabethkingia miricola infection: A case report

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.965939

DOI=10.3389/fneur.2022.965939

ISSN=1664-2295

ABSTRACT=<p><italic>Elizabethkingia miricola</italic> (<italic>E. miricola</italic>) is an extremely rare pathogenic bacterium, which causes serious infections in patients with primary immunodeficiency or tumors, and it is often misdiagnosed. <italic>E. miricola</italic> has rarely been known to cause a neurologic infection. We describe the first case of acute bacterial encephalitis associated with <italic>E. miricola</italic> infection in a man with recurrent nasopharyngeal carcinoma, which was successfully cured by antibiotics. The patient initially presented with recurrent episodes of fever and later showed impaired consciousness but these symptoms were alleviated with antibiotic therapy including cefoperazone/sulbactam. This study highlights that rapid and accurate pathogen detection <italic>via</italic> metagenomic next-generation sequencing and early use of appropriate antibiotics can improve the prognosis of patients with suspected neurologic <italic>E. miricola</italic> infection. Early treatment for underlying primary diseases can also significantly improve the outcomes of patients.</p>