AUTHOR=Li Xiaoqin , Li Lingfei , Si Xiaoli , Zhang Zheng , Ni Zhumei , Zhou Yongji , Liu Keqin , Xia Wenqing , Zhang Yuyao , Gu Xin , Huang Jinyu , Yin Congguo , Shao Anwen , Jiang Lin TITLE=The regulatory roles of circular RNAs via autophagy in ischemic stroke JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.963508 DOI=10.3389/fneur.2022.963508 ISSN=1664-2295 ABSTRACT=

Ischemic stroke (IS) is a severe disease with a high disability, recurrence, and mortality rates. Autophagy, a highly conserved process that degrades damaged or aging organelles and excess cellular components to maintain homeostasis, is activated during IS. It influences the blood–brain barrier integrity and regulates apoptosis. Circular RNAs (circRNAs) are novel non-coding RNAs involved in IS-induced autophagy and participate in various pathological processes following IS. In addition, they play a role in autophagy regulation. This review summarizes current evidence on the roles of autophagy and circRNA in IS and the potential mechanisms by which circRNAs regulate autophagy to influence IS injury. This review serves as a basis for the clinical application of circRNAs as novel biomarkers and therapeutic targets in the future.