AUTHOR=Gaulee Pratima , Yang Zhihui , Sura Livia , Xu Haiyan , Rossignol Candace , Weiss Michael D. , Bliznyuk Nikolay 

TITLE=Concentration of Serum Biomarkers of Brain Injury in Neonates With a Low Cord pH With or Without Mild Hypoxic-Ischemic Encephalopathy

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.934755

DOI=10.3389/fneur.2022.934755

ISSN=1664-2295

ABSTRACT=<sec><title>Objective</title><p>To determine the concentrations of four neuroprotein biomarkers and 68 miRNAs in neonates with low cord pH and/or mild hypoxic-ischemic encephalopathy (HIE).</p></sec><sec><title>Study Design</title><p>A prospective cohort study enrolled neonates with low cord pH (<italic>n</italic> = 18), moderate-severe HIE (<italic>n</italic> = 40), and healthy controls (<italic>n</italic> = 38). Groups provided serum samples at 0–6 h of life. The concentrations of biomarkers and miRNAs were compared between cohorts.</p></sec><sec><title>Result</title><p>The low cord pH and moderate-severe HIE groups had increased concentrations of GFAP, NFL and Tau compared to controls (<italic>P</italic> &lt; 0.05, <italic>P</italic> &lt; 0.001, respectively). NFL concentrations in mild HIE was higher than controls (<italic>P</italic> &lt; 0.05) but less than moderate-severe HIE (<italic>P</italic> &lt; 0.001). Of 68 miRNAs, 36 in low cord pH group and 40 in moderate-severe HIE were upregulated compared to controls (<italic>P</italic> &lt; 0.05). Five miRNAs in low cord pH group (<italic>P</italic> &lt; 0.05) and 3 in moderate-severe HIE were downregulated compared to controls (<italic>P</italic> &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>A biomarker panel in neonates with low cord pH may help clinicians make real-time decisions.</p></sec>