AUTHOR=Ren Linan , Gang Xiaokun , Yang Shuo , Sun Meixin , Wang Guixia TITLE=A new perspective of hypothalamic disease: Shapiro's syndrome JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.911332 DOI=10.3389/fneur.2022.911332 ISSN=1664-2295 ABSTRACT=

Shapiro's syndrome (SS) is characterized by spontaneous periodic hypothermia. It occurs to patients regardless of age or sex. To date, <60 cases have been reported worldwide. Current knowledge of the disease is limited to clinical feature since the pathogenesis and etiology are still controversial. In this review, the clinical characteristics, pathological mechanism, and possible etiology of the syndrome were reviewed to improve the clinical understanding of the disease.