AUTHOR=Zhang Jeff F. , Nickerson Kevin , Piryani Ravi , Farooq Osman , Swayampakula Anil K. 

TITLE=Macroglossia Associated With Clobazam Administration: A Case Report and Literature Review

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.900763

DOI=10.3389/fneur.2022.900763

ISSN=1664-2295

ABSTRACT=<p>Clobazam is a benzodiazepine derivative used as an antiepileptic agent for the treatment of focal and generalized seizures and drug-resistant epilepsy associated with Lennox-Gastaut Syndrome. While somnolence and mood-related side effects are commonly observed, acute macroglossia following initiation of Clobazam therapy has not been previously reported in the medical literature. In this case report, we present a female pediatric patient who developed significant tongue swelling with protrusion beyond the oral cavity after initiation of Clobazam for treatment-resistant epilepsy. Symptoms were unresponsive to antihistamines and steroids but resolved gradually in the days following discontinuation of Clobazam with no lingering sequelae.</p>