AUTHOR=Cui Ting , Wang Changyi , Zhu Qiange , Li Shucheng , Yang Yuan , Wang Anmo , Zhang Xuening , Shang Wenzuo , Wu Bo 

TITLE=Association between neutrophil percentage-to-albumin ratio and 3-month functional outcome in acute ischemic stroke patients with reperfusion therapy

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.898226

DOI=10.3389/fneur.2022.898226

ISSN=1664-2295

ABSTRACT=<sec><title>Background</title><p>Neutrophils and albumin are associated with outcomes in patients with acute ischemic stroke (AIS). We aimed to explore the association between the neutrophil percentage-to-albumin ratio (NPAR), a novel marker of inflammation and oxidative stress, and the 3-month functional outcome in AIS patients with reperfusion therapy.</p></sec><sec><title>Methods</title><p>This single-center, retrospective cohort study consecutively enrolled AIS patients with reperfusion therapy. Neutrophils and albumin were collected on admission. The primary outcome was a poor functional outcome, which was defined as a modified Rankin scale score of 3–6 at 3 months.</p></sec><sec><title>Results</title><p>A total of 647 patients with AIS who received reperfusion therapy were analyzed. The mean age was 68.9 ± 13.9 years, and 358 (55.3%) of the patients were men. The median NPAR was 1.89 (interquartile range [IQR] 1.64–2.09). The percentage of patients with a 3-month poor functional outcome was 57.0% (369/647). NPAR was positively associated with a poor functional outcome (odds ratio [<italic>OR</italic>] 2.76, 95% <italic>CI</italic>: 1.52–5.03, <italic>p</italic> = 0.001). When patients were classified into tertiles, patients in the upper tertile (2.03–7.59) had a higher risk of poor outcome than patients in the lower tertile after adjusting for potential confounders (0.78–1.73) (<italic>OR</italic> 2.10, 95% <italic>CI</italic>: 1.28–3.42, <italic>p</italic> = 0.003). The risk of poor outcome increased with NPAR tertiles (<italic>p</italic>-trend = 0.003). The optimal cut-off value of the NPAR for predicting a poor outcome was 1.72, with a sensitivity of 0.75, and a specificity of 0.43.</p></sec><sec><title>Conclusion</title><p>Neutrophil percentage-to-albumin ratio was significantly associated with 3-month poor functional outcomes in patients with AIS who received reperfusion therapy.</p></sec>