AUTHOR=Guo Yingwei , Yang Yingjian , Cao Fengqiu , Liu Yang , Li Wei , Yang Chaoran , Feng Mengting , Luo Yu , Cheng Lei , Li Qiang , Zeng Xueqiang , Miao Xiaoqiang , Li Longyu , Qiu Weiyan , Kang Yan 

TITLE=Radiomics features of DSC-PWI in time dimension may provide a new chance to identify ischemic stroke

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.889090

DOI=10.3389/fneur.2022.889090

ISSN=1664-2295

ABSTRACT=<p>Ischemic stroke has become a severe disease endangering human life. However, few studies have analyzed the radiomics features that are of great clinical significance for the diagnosis, treatment, and prognosis of patients with ischemic stroke. Due to sufficient cerebral blood flow information in dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) images, this study aims to find the critical features hidden in DSC-PWI images to characterize hypoperfusion areas (HA) and normal areas (NA). This study retrospectively analyzed 80 DSC-PWI data of 56 patients with ischemic stroke from 2013 to 2016. For exploring features in HA and NA,13 feature sets (<italic>F</italic><sub><italic>method</italic></sub>) were obtained from different feature selection algorithms. Furthermore, these 13 <italic>F</italic><sub><italic>method</italic></sub> were validated in identifying HA and NA and distinguishing the proportion of ischemic lesions in brain tissue. In identifying HA and NA, the composite score (CS) of the 13 <italic>F</italic><sub><italic>method</italic></sub> ranged from 0.624 to 0.925. <italic>F</italic><sub><italic>Lasso</italic></sub> in the 13 <italic>F</italic><sub><italic>method</italic></sub> achieved the best performance with mAcc of 0.958, mPre of 0.96, mAuc of 0.982, mF1 of 0.959, and mRecall of 0.96. As to classifying the proportion of the ischemic region, the best CS was 0.786, with Acc of 0.888 and Pre of 0.863. The classification ability was relatively stable when the reference threshold (<italic>RT</italic>) was &lt;0.25. Otherwise, when <italic>RT</italic> was &gt;0.25, the performance will gradually decrease as its increases. These results showed that radiomics features extracted from the Lasso algorithms could accurately reflect cerebral blood flow changes and classify HA and NA. Besides, In the event of ischemic stroke, the ability of radiomics features to distinguish the proportion of ischemic areas needs to be improved. Further research should be conducted on feature engineering, model optimization, and the universality of the algorithms in the future.</p>