AUTHOR=Garés-Caballer Marta , Sánchez-Ortí Joan Vicent , Correa-Ghisays Patricia , Balanzá-Martínez Vicent , Selva-Vera Gabriel , Vila-Francés Joan , Magdalena-Benedito Rafael , San-Martin Constanza , Victor Victor M. , Escribano-Lopez Irene , Hernandez-Mijares Antonio , Vivas-Lalinde Juliana , Vieta Eduard , Leza Juan C. , Tabarés-Seisdedos Rafael 

TITLE=Immune–Inflammatory Biomarkers Predict Cognition and Social Functioning in Patients With Type 2 Diabetes Mellitus, Major Depressive Disorder, Bipolar Disorder, and Schizophrenia: A 1-Year Follow-Up Study

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.883927

DOI=10.3389/fneur.2022.883927

ISSN=1664-2295

ABSTRACT=<sec><title>Background</title><p>Systemic, low-grade immune–inflammatory activity, together with social and neurocognitive performance deficits are a transdiagnostic trait of people suffering from type 2 diabetes mellitus (T2DM) and severe mental illnesses (SMIs), such as schizophrenia (SZ), major depressive disorder (MDD), and bipolar disorder (BD). We aimed to determine if immune–inflammatory mediators were significantly altered in people with SMIs or T2DM compared with healthy controls (HC) and whether these biomarkers could help predict their cognition and social functioning 1 year after assessment.</p></sec><sec><title>Methods</title><p>We performed a prospective, 1-year follow-up cohort study with 165 participants at baseline (TB), including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 HC; and 125 at 1-year follow-up (TY), and determined executive domain (ED), global social functioning score (GSFS), and peripheral blood immune–inflammatory and oxidative stress biomarkers.</p></sec><sec><title>Results</title><p>Participants with SMIs and T2DM showed increased peripheral levels of inflammatory markers, such as interleukin-10 (<italic>p</italic> &lt; 0.01; η<sup>2</sup><italic>p</italic> = 0.07) and tumor necrosis factor-α (<italic>p</italic> &lt; 0.05; η<sup>2</sup><italic>p</italic> = 0.08); and oxidative stress biomarkers, such as reactive oxygen species (ROS) (<italic>p</italic> &lt; 0.05; η<sup>2</sup><italic>p</italic> = 0.07) and mitochondrial ROS (<italic>p</italic> &lt; 0.01; η<sup>2</sup><italic>p</italic> = 0.08). The different combinations of the exposed biomarkers anticipated 46–57.3% of the total ED and 23.8–35.7% of GSFS for the participants with SMIs.</p></sec><sec><title>Limitations</title><p>Participants' treatment, as usual, was continued without no specific interventions; thus, it was difficult to anticipate substantial changes related to the psychopharmacological pattern.</p></sec><sec><title>Conclusion</title><p>People with SMIs show significantly increased levels of peripheral immune–inflammatory biomarkers, which may contribute to the neurocognitive and social deficits observed in SMIs, T2DM, and other diseases with systemic immune–inflammatory activation of chronic development. These parameters could help identify the subset of patients who could benefit from immune–inflammatory modulator strategies to ameliorate their functional outcomes.</p></sec>