AUTHOR=Li Hongmin , Sheng Zhaofu , Khan Suliman , Zhang Ruiyi , Liu Yang , Zhang Yan , Yong V. Wee , Xue Mengzhou TITLE=Matrix Metalloproteinase-9 as an Important Contributor to the Pathophysiology of Depression JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.861843 DOI=10.3389/fneur.2022.861843 ISSN=1664-2295 ABSTRACT=

Matrix metalloproteinases (MMPs) are physiologically expressed in the central nervous system in neurons, astrocytes and microglia, and their aberrant elevation contributes to a number of diseases. Amongst the MMP members, MMP−9 has generated considerable attention because of its possible involvement in inflammatory responses, blood-brain barrier permeability, the regulation of perineuronal nets, demyelination, and synaptic long-term potentiation. Emerging evidence indicate an association between MMP−9 and the syndrome of depression. This review provides an updated and comprehensive summary of the probable roles of MMP−9 in depression with an emphasis on the mechanisms and potential of MMP−9 as a biomarker of depression.