AUTHOR=Sussman Bethany L. , Wyckoff Sarah N. , Heim Jennifer , Wilfong Angus A. , Adelson P. David , Kruer Michael C. , Gonzalez Maria Jose , Boerwinkle Varina L. TITLE=Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.847834 DOI=10.3389/fneur.2022.847834 ISSN=1664-2295 ABSTRACT=

In the evolving modern era of neuromodulation for movement disorders in adults and children, much progress has been made recently characterizing the human motor network (MN) with potentially important treatment implications. Herein is a focused review of relevant resting state fMRI functional and effective connectivity of the human motor network across the lifespan in health and disease. The goal is to examine how the transition from functional connectivity to dynamic effective connectivity may be especially informative of network-targeted movement disorder therapies, with hopeful implications for children.