AUTHOR=Pohlan Julian , Nawabi Jawed , Witham Denis , Schroth Luna , Krause Finn , Schulze Jan , Gelen Simon , Ahlborn Robert , Rubarth Kerstin , Dewey Marc 

TITLE=Cerebrovascular Events in Suspected Sepsis: Retrospective Prevalence Study in Critically Ill Patients Undergoing Full-Body Computed Tomography

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.811022

DOI=10.3389/fneur.2022.811022

ISSN=1664-2295

ABSTRACT=<sec><title>Purpose</title><p>This study aimed at retrospectively evaluating full-body computed tomography (CT) examinations for the prevalence of cerebrovascular events in patients with suspected sepsis treated in the intensive care unit (ICU).</p></sec><sec><title>Methods</title><p>All full-body CT examinations, i.e., both cranial CT (cCT) and body CT including chest, abdomen and pelvis, for focus search in septic patients over a 12-months period were identified from three ICUs, using full-text search. From this retrospective cohort, we fully analyzed 278 cCT examinations for the occurrence of acute cerebral findings. All acute cerebrovascular events were independently reviewed by two blinded readers. Clinical and laboratory findings were extracted. The data were statistically analyzed using contingency tests.</p></sec><sec><title>Results</title><p>In our population of patients with suspected sepsis, 10.8% (<italic>n</italic> = 30/278) were identified to have major cerebral events, including 7.2% (<italic>n</italic> = 20/278) major cerebrovascular events and 4.3% (<italic>n</italic> = 12/278) generalized parenchymal damage. 13.4% (<italic>n</italic> = 22/163) of patients with a severe coma as compared with non-severe coma, 4.4% (<italic>n</italic> = 3/68), showed a major cerebral event (<italic>p</italic> = 0.04). Patients referred from the cardiology/nephrology ICU ward showed major cerebral events in 16.3% (<italic>n</italic> = 22/135), as compared with 4.9% (<italic>n</italic> = 3/61) in patients from pulmonary ICU and 6.1% (<italic>n</italic> = 5/82) major cerebral events with surgical referral (<italic>p</italic> = 0.02).</p></sec><sec><title>Conclusion</title><p>Our study provides further evidence that septic patients may suffer from cerebral events with relevance to their prognosis. Severe coma and the referring ward were associated with acute cerebral conditions. Full-body CT has the advantage of both detecting of septic foci and possibly identifying ischemic or hemorrhagic stroke in this vulnerable patient population.</p></sec>