AUTHOR=Yao Taotao , Di Anqi , Li Jialing , Zhang Shuchen , He Jun , Xu Nuo , Xu Danghan 

TITLE=Association Between Serum Uric Acid and Intracranial Arterial Stenosis in a Korean Population: A Secondary Analysis Based on a Cross-Sectional Study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.791456

DOI=10.3389/fneur.2022.791456

ISSN=1664-2295

ABSTRACT=Abstract
Background and Purpose: Intracranial arterial stenosis is a common cause of cerebrovascular disease. Studies have shown that the disease may be associated with elevated serum uric acid. However, the results remain inexact and controversial. To provide theoretical support for clinical practice, we assessed the relationship between uric acid and intracranial arterial stenosis (ICAS) based on previous literature.
Materials and Methods: A total of 1011 samples were included in the secondary cross-sectional study we investigated. We evaluated the relationship between uric acid level and ICAS using multivariable logistic regression analysis.
Results: The mean age was 64.16 ± 9.13 years of age, and 35.51% (n=359) of patients were male in the study. One hundred and one (10%) of the included participants had ICAS. In the unadjusted model, uric acid level was positively associated with ICAS (odds ratio [OR] =1.23, 95% confidence interval [CI]: 1.07-1.42, P<0.01). After adjusting for potential confounders (sex, age, diabetes mellitus,  coronary artery occlusive disease, hyperlipidemia, statin medication, hypertension, and fasting glucose), a positive relationship was observed between uric acid and ICAS (OR=1.26, 95% CI: 1.08-1.47, P < 0.05).
Conclusion: There was a positive relationship between uric acid levels and ICAS in neurologically healthy Korean participants.