AUTHOR=Wang Yicong , Chen Weiqi , Zhou Jian , Wang Yongjun , Wang Hao , Wang Yilong 

TITLE=Nitrate Metabolism and Ischemic Cerebrovascular Disease: A Narrative Review

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.735181

DOI=10.3389/fneur.2022.735181

ISSN=1664-2295

ABSTRACT=<p>Inorganic and organic nitrates are present <italic>in vivo</italic> and <italic>in vitro</italic>. Inorganic nitrate is considered a pool of nitric oxide (NO), but it can be converted into nitrite and NO through various mechanisms. It plays an important role in the regulation of complex physiological and biochemical reactions, such as anti-inflammatory processes and the inhibition of platelet aggregation, which are closely related to the pathology and treatment of cerebrovascular disease. Ischemic cerebrovascular disease is characterized by high incidence, recurrence, and disability rates. Nitrate, nitrite, and NO were recently found to be involved in cerebrovascular disease. In this review, we describe the relationship between cerebrovascular disease and nitrate metabolism to provide a basis for further advances in laboratory and clinical medicine.</p>