AUTHOR=Huang Shuangfeng , Huang Qianqian , Zhou Zhongbao , Zhang Junliang , Zhan Yan , Liang Zhigang 

TITLE=The Efficacy of V. odorata Extract in the Treatment of Insomnia: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.730311

DOI=10.3389/fneur.2022.730311

ISSN=1664-2295

ABSTRACT=<sec><title>Aim</title><p>This systematic review and meta-analysis was performed to assess the effect of <italic>Viola odorata</italic> (<italic>V. odorata</italic>) extract in the treatment of insomnia.</p></sec><sec><title>Methods</title><p>PubMed, EMBASE, and Cochrane Library databases, as well as references of related articles, were searched. Finally, four articles with five clinical trials including 224 patients were included in the analysis.</p></sec><sec><title>Results</title><p>The obtained results indicated a greater improvement in total PSQI scores (MD,−4.67; <italic>P</italic> = 0.0002), subjective sleep quality score (MD,−0.91; <italic>P</italic> = 0.003), sleep duration score (MD,−0.77; <italic>P</italic> &lt; 0.00001), and ISI score (MD,−6.30; <italic>P</italic> = 0.009) in the Viola extract group compared with the placebo group. However, the Viola extract group did not significantly differ in sleep latency (MD,−0.85; <italic>P</italic> = 0.08), habitual sleep efficiency (MD,−0.61; <italic>P</italic> = 0.21), sleep disturbances (MD,−0.36; <italic>P</italic> = 0.11), and daytime dysfunction (MD,−0.94; <italic>P</italic> = 0.12) from the placebo group.</p></sec><sec><title>Conclusions</title><p><italic>Viola</italic> extract supplement led to a greater improvement in total PSQI scores, subjective sleep quality score, sleep duration score, and ISI score compared with the placebo group of patients with chronic insomnia.</p></sec>