AUTHOR=Hao Lei , Yang Yongtao , Xu Xiaoli , Guo Xiuming , Zhan Qunling TITLE=Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2023 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1073958 DOI=10.3389/fneur.2022.1073958 ISSN=1664-2295 ABSTRACT=
Ischemic stroke accounts for 70–80% of all stroke cases. Immunity plays an important role in the pathophysiology of ischemic stroke. Microglia are the first line of defense in the central nervous system. Microglial functions are largely dependent on their pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotype. Modulating neuroinflammation