AUTHOR=Papasavva Maria , Vikelis Michail , Siokas Vasileios , Katsarou Martha-Spyridoula , Dermitzakis Emmanouil V. , Raptis Athanasios , Kalliantasi Aikaterini , Dardiotis Efthimios , Drakoulis Nikolaos 

TITLE=Variability in oxidative stress-related genes (SOD2, CAT, GPX1, GSTP1, NOS3, NFE2L2, and UCP2) and susceptibility to migraine clinical phenotypes and features

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1054333

DOI=10.3389/fneur.2022.1054333

ISSN=1664-2295

ABSTRACT=<sec><title>Introduction</title><p>Migraine is a complex disorder with genetic and environmental inputs. Cumulative evidence implicates oxidative stress (OS) in migraine pathophysiology while genetic variability may influence an individuals' oxidative/antioxidant capacity. Aim of the current study was to investigate the impact of eight common OS-related genetic variants [rs4880 (<italic>SOD2</italic>), rs1001179 (<italic>CAT</italic>), rs1050450 (<italic>GPX1</italic>), rs1695 (<italic>GSTP1</italic>), rs1138272 (<italic>GSTP1</italic>), rs1799983 (<italic>NOS3</italic>), rs6721961 (<italic>NFE2L2</italic>), rs660339 (<italic>UCP2</italic>)] in migraine susceptibility and clinical features in a South-eastern European Caucasian population.</p></sec><sec><title>Methods</title><p>Genomic DNA samples from 221 unrelated migraineurs and 265 headache-free controls were genotyped for the selected genetic variants using real-time PCR (melting curve analysis).</p></sec><sec><title>Results</title><p>Although allelic and genotypic frequency distribution analysis did not support an association between migraine susceptibility and the examined variants in the overall population, subgroup analysis indicated significant correlation between <italic>NOS3</italic> rs1799983 and migraine susceptibility in males. Furthermore, significant associations of <italic>CAT</italic> rs1001179 and <italic>GPX1</italic> rs1050450 with disease age-at-onset and migraine attack duration, respectively, were revealed. Lastly, variability in the <italic>CAT, GSTP1</italic> and <italic>UCP2</italic> genes were associated with sleep/weather changes, alcohol consumption and physical exercise, respectively, as migraine triggers.</p></sec><sec><title>Discussion</title><p>Hence, the current findings possibly indicate an association of OS-related genetic variants with migraine susceptibility and clinical features, further supporting the involvement of OS and genetic susceptibility in migraine.</p></sec>