AUTHOR=Raftopoulou Sylvia , Rapti Anna , Karathanasis Dimitris , Evangelopoulos Maria Eleftheria , Mavragani Clio P. 

TITLE=The role of type I IFN in autoimmune and autoinflammatory diseases with CNS involvement

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1026449

DOI=10.3389/fneur.2022.1026449

ISSN=1664-2295

ABSTRACT=<p>Type I interferons (IFNs) are major mediators of innate immunity, with well-known antiviral, antiproliferative, and immunomodulatory properties. A growing body of evidence suggests the involvement of type I IFNs in the pathogenesis of central nervous system (CNS) manifestations in the setting of chronic autoimmune and autoinflammatory disorders, while IFN-β has been for years, a well-established therapeutic modality for multiple sclerosis (MS). In the present review, we summarize the current evidence on the mechanisms of type I IFN production by CNS cellular populations as well as its local effects on the CNS. Additionally, the beneficial effects of IFN-β in the pathophysiology of MS are discussed, along with the contributory role of type I IFNs in the pathogenesis of neuropsychiatric lupus erythematosus and type I interferonopathies.</p>