AUTHOR=Zhang Xiaohao , Zhou Feng , Wang Wei , E Yan , Chen Shuaiyu , Cao Haiming , Lian Huiwen , Jiang Teng , Zhang Yingdong , Shi Hongchao , Zhou Junshan 

TITLE=Levels of adhesion molecules and clinical outcomes in patients with ischemic stroke after mechanical thrombectomy

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1024162

DOI=10.3389/fneur.2022.1024162

ISSN=1664-2295

ABSTRACT=<sec><title>Background and purpose</title><p>Data on adhesion molecule levels in patients treated with mechanical thrombectomy (MT) are scarce. We aimed to evaluate the association among adhesion molecule levels, symptomatic intracranial hemorrhage (sICH), and clinical outcome and to determine whether the sICH influences the association of adhesion molecules with functional outcome.</p></sec><sec><title>Methods</title><p>Patients with large artery occlusion in the anterior circulation and treated with MT were prospectively recruited. Adhesion molecules, such as soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble E-selectin (sE-selectin) were tested. An unfavorable outcome was defined as a 90-day modified Rankin Scale (mRS) score of 3–6. The sICH was diagnosed according to the Heidelberg Bleeding Classification within 72 h of endovascular treatment (EVT).</p></sec><sec><title>Results</title><p>Of the 310 enrolled patients (mean age, 68.5 years; 198 men), 46 (14.8%) experienced sICH and 173 (55.8%) experienced an unfavorable outcome at 90 days. After adjusting for potential confounders, patients with higher sVCAM-1 and sE-selectin levels had an increasing trend of sICH [4th quartile vs. 1st quartile for sVCAM-1; odds ratio (<italic>OR</italic>), 2.766, <italic>p</italic> = 0.085; sE-selectin; <italic>OR</italic>, 2.422, <italic>p</italic> = 0.086] and poor outcome (4th quartile vs. 1st quartile for sVCAM-1; <italic>OR</italic>, 2.614, <italic>p</italic> = 0.025; sE-selectin; <italic>OR</italic>, 2.325, <italic>p</italic> = 0.046). Furthermore, the sICH might partially mediate the worse functional outcome in patients with higher adhesion molecules levels (Sobel test, <italic>p</italic> &lt; 0.001 for sVCAM-1 and <italic>p</italic> = 0.007 for sE-selectin).</p></sec><sec><title>Conclusions</title><p>There were significant relationships between levels of adhesion molecules and a 90-day poor outcome in patients with ischemic stroke treated with MT, which was partially mediated by sICH.</p></sec>