AUTHOR=Li Kaixiu , Wang Qun , Wang Liqiang , Huang Yifei TITLE=Cognitive dysfunctions in high myopia: An overview of potential neural morpho-functional mechanisms JOURNAL=Frontiers in Neurology VOLUME=13 YEAR=2022 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1022944 DOI=10.3389/fneur.2022.1022944 ISSN=1664-2295 ABSTRACT=

Dementia and cognitive impairment (CIM) carry high levels of mortality. Visual impairment (VI) is linked with CIM risk. High myopia (HM) is a chronic disease frequently leading to irreversible blindness. Current opinion has shifted from retinal injury as the cause of HM to the condition being considered an eye-brain disease. However, the pathogenesis of this disease and the manner in which neural structures are damaged are poorly understood. This review comprehensively discusses the relationship between HM, the central nervous system, and CIM, together with the novel concept of three visual pathways, and possible research perspectives.