AUTHOR=Cai Heng , Yang Fangyu , Xu Yousong , Geng Yu , Li Jinwei , Li Yugang , Fu Kailei , Liu Chang , Wang Meiyan , Li Zhiqing 

TITLE=A multicenter retrospective controlled study of the Pipeline™ and Tubridge™ Flow Diverter devices for intracranial wide-necked aneurysms

JOURNAL=Frontiers in Neurology

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2022.1014596

DOI=10.3389/fneur.2022.1014596

ISSN=1664-2295

ABSTRACT=<sec><title>Purpose</title><p>To compare the safety and efficacy of Pipeline<sup>TM</sup> and Tubridge<sup>TM</sup> Flow Diverter devices (FDs) in the treatment of intracranial wide-necked aneurysms.</p></sec><sec><title>Methods</title><p>We retrospectively analyzed the clinical data of 92 patients with intracranial wide-necked aneurysms who were treated with those two flow-diverter devices (FDs) at four participating centers between July 2012 and December 2020.</p></sec><sec><title>Results</title><p>This study included 92 patients who underwent endovascular therapy using either Pipeline™ (<italic>n</italic> = 39) or Tubridge<sup>TM</sup> (<italic>n</italic> = 53) for treating intracranial wide-necked aneurysms. The periprocedural complication developed in 2.56% (1/39) patients of Pipeline group and 3.77% (2/53) patients of the Tubridge<sup>TM</sup> group. During perioperative period, one patient in Pipeline™ group showed subarachnoid hemorrhage (2.56%, 1/39) and two ischemic complications in the Tubridge™ group (3.77%, 2/53). Follow-up assessments were conducted on 31 patients (79.49%) in the Pipeline™ group (the mean follow-up period was 9.7 ± 3.3 months). The rate of complete aneurysm occlusion at the final angiographic follow-up was 77.42%. Patients with a modified Rankin scale (mRS) score of 0.44 ± 0.31. Follow-up assessments were conducted on 42 patients (79.25%) in the Tubridge<sup>TM</sup> group (the mean follow-up period was 9.1 ± 4.4 months). The rate of complete aneurysm occlusion at the final angiographic follow-up was 85.71%. Patients with mRS score of 0.52 ± 0.28. Three patients showed parent artery stenosis, and one showed parent artery occlusion.</p></sec><sec><title>Conclusion</title><p>Both the Pipeline<sup>TM</sup> and Tubridge<sup>TM</sup> are safe and effective for the treatment of intracranial wide-necked aneurysms, with no significant difference in the rate of complete aneurysm occlusion and perioperative complications between the two FDs.</p></sec>