AUTHOR=Zhong Rui , Chen Qingling , Zhang Xinyue , Lin Weihong 

TITLE=The Occurrence of Seizure Clusters in Patients With Epilepsy Is Partly Determined by Epilepsy Severity: A Single-Center Retrospective Observational Study

JOURNAL=Frontiers in Neurology

VOLUME=Volume 12 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.794086

DOI=10.3389/fneur.2021.794086

ISSN=1664-2295

ABSTRACT=Abstract
Purpose: The aim of this retrospective observational study was to investigate the self-reported prevalence of seizure clusters (CSs) in patients with epilepsy (PWE) and its relationship with clinical characteristics.

Methods: We retrospectively analysed data from consecutive PWE from our hospital in northeastern China. Data were collected from the databank of a tertiary epilepsy centre. Logistic regression models were employed to investigate the relationships between individual patient demographic/clinical variables and the occurrence of SC.

Results: In total, 606 consecutive PWE were included in the final analysis, and 268 (44.2%) patients experienced at least one seizure cluster. In multivariate logistic regression models, age (OR: 1.014; 95% CI: 1.002–1.027; p=0.02), seizure frequency (OR: 2.08; 95% CI: 1.555–2.783; p＜0.001), multiple seizure types (OR: 5.111; 95% CI: 1.737–15.043; p=0.003), number of current anti-seizure medications (ASM) (OR: 1.533; 95% CI: 1.15–2.042; p=0.004), drug-resistant epilepsy (OR: 1.987; 95% CI: 1.159–3.407; p=0.013), and a history of status epilepticus (OR: 1.903; 95% CI: 1.24–2.922; p=0.003) were independent variables associated with a history of SC in PWE.

Conclusion: Seizure clusters are common occurrences at our study centre. The occurrence of SC in individuals with epilepsy, to some extent, is determined by the epilepsy severity.