AUTHOR=Li Yin , Ma Zhenjiang , Ren Ya , Lu Dezhi , Li Tao , Li Wentao , Wang Jinwu , Ma Hui , Zhao Jie 

TITLE=Tissue Engineering Strategies for Peripheral Nerve Regeneration

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.768267

DOI=10.3389/fneur.2021.768267

ISSN=1664-2295

ABSTRACT=<p>A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. In recent years, many constructive nerve regeneration schemes are proposed at home and abroad. Nerve tissue engineering plays an important role. It develops an ideal nerve substitute called artificial nerve. Given the complexity of nerve regeneration, this review summarizes the pathophysiology and tissue-engineered repairing strategies of the PNI. Moreover, we discussed the scaffolds and seed cells for neural tissue engineering. Furthermore, we have emphasized the role of 3D printing in tissue engineering.</p>