AUTHOR=Kameyama Masashi , Momose Toshimitsu , Ishibashi Kenji , Ishii Kenji 

TITLE=A Novel Proposal for an Index for Regional Cerebral Perfusion Pressure – A Theoretical Approach Using Fluid Dynamics

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2022

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.765463

DOI=10.3389/fneur.2021.765463

ISSN=1664-2295

ABSTRACT=<p>Cerebral blood flow (CBF) / cerebral blood volume (CBV) ratio derived by [<sup>15</sup>O] H<sub>2</sub>O/ CO<sub>2</sub> and CO positron emission tomography (PET) examination has been used as an index for cerebral perfusion pressure (CPP). CBF/CBV was demonstrated to be related mean arterial pressure (MAP) in baboons. However, this formula has not been confirmed to be proportionate to CPP. We have developed a new index for CPP using the Poiseuille equation based on a simple model. Our model suggests that CBF/CBV<sup>2</sup> is proportionate to CPP and that it is mathematically a more accurate index than CBF/CBV. This new index needs experimental validation in the future.</p>