AUTHOR=Xiao Yi , Ou Ruwei , Yang Tianmi , Liu Kuncheng , Wei Qianqian , Hou Yanbing , Zhang Lingyu , Lin Junyu , Shang Huifang 

TITLE=Different Associated Factors of Subjective Cognitive Complaints in Patients With Early- and Late-Onset Parkinson's Disease

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.749471

DOI=10.3389/fneur.2021.749471

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> Subjective cognitive complaints (SCCs), which are associated with a higher risk of cognitive decline, are widespread in the patients with Parkinson's disease (PD). The previous studies have reported inconsistent factors related to SCCs in the patients with late-onset PD (LOPD), and there is limited information on SCCs in the patients with early-onset PD (EOPD).</p><p><bold>Objective:</bold> We aimed to investigate the factors associated with SCCs in the drug-naïve patients with EOPD and LOPD without cognitive impairment.</p><p><bold>Methods:</bold> This cross-sectional study included 332 drug-naïve patients with PD, among whom 134 were EOPD and 198 were LOPD. Motor and non-motor symptoms, such as global objective cognitive status, depression, anxiety, apathy, fatigue, sleep, rapid eye movement sleep behavior disorder, orthostatic hypotension, and excessive daytime sleepiness, were assessed.</p><p><bold>Results:</bold> Twenty-five (18.66%) patients with EOPD and 49 (24.74%) patients with LOPD reported SCCs. A multivariate binary logistic regression analysis revealed that older age at onset [odds ratio (<italic>OR</italic>) = 1.24, <italic>P</italic> = 0.002], higher apathy score (<italic>OR</italic> = 1.13, <italic>P</italic> = 0.003), and lower scores in the visuospatial/executive abilities (<italic>OR</italic> = 0.25, <italic>P</italic> &lt; 0.001) and memory (<italic>OR</italic> = 0.50, <italic>P</italic> = 0.024) domains of the Montreal Cognitive Assessment were associated with a higher risk of SCCs in the EOPD group. Higher apathy (<italic>OR</italic> = 1.06, <italic>P</italic> = 0.011) and anxiety (<italic>OR</italic> = 1.14, <italic>P</italic> &lt; 0.001) scores were associated with SCCs in the LOPD group.</p><p><bold>Conclusion:</bold> Subjective cognitive complaints are only associated with mood disorders in patients with LOPD. In addition, SCCs may reflect subthreshold cognitive impairment in the patients with EOPD.</p>