AUTHOR=Ding Yarong , Xu Zhe , Pan Yuesong , Meng Xia , Xiang Xianglong , Li Hao , Liu Liping , Wang Yongjun 

TITLE=Association Between CST3 Gene Polymorphisms and Large-Artery Atherosclerotic Stroke

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.738148

DOI=10.3389/fneur.2021.738148

ISSN=1664-2295

ABSTRACT=<p><bold>Objective:</bold> Cystatin C, a marker of atherosclerosis, is encoded by <italic>CST3</italic>. We aimed to evaluate whether two single-nucleotide polymorphisms (SNPs) of <italic>CST3</italic> are correlated with large-artery atherosclerotic stroke (LAAS) and prognosis.</p><p><bold>Methods:</bold> This subgroup analysis of the Third China National Stroke Registry (CNSR-III) enrolled acute ischemic stroke (AIS) patients within 7 days from August 2015 to March 2018 in China. rs13038305 and rs911119 of <italic>CST3</italic> were selected based on the strong association with cystatin C concentration.</p><p><bold>Results:</bold> Two loci of <italic>CST3</italic> (rs13038305 and rs911119) were analyzed in 3,833 ischemic stroke patients. Carriers of T allele in rs13038305 and C allele in rs911119 tend to have lower serum cystatin C levels (<italic>p</italic> &lt; 0.05). Compared with C/C as a reference in rs13038305, odds ratio (OR) of T/T was 0.486, 95% CI 0.237–0.994, <italic>p</italic> = 0.048. Per C allele of rs13038305 also showed an increased level of low-density lipoprotein cholesterol (LDL-C), β (95% CI) was 1.335 (1.008–1.250), <italic>p</italic> = 0.044. No correlation was found between the selected SNPs and stroke prognosis (functional outcome, recurrence, and mortality).</p><p><bold>Conclusions:</bold> Carriers of the T allele in rs13038305 tend to have a lower proportion of LAAS. rs13038305 and rs911119 polymorphisms were likely to affect cystatin C concentration independently of kidney function.</p>