AUTHOR=Qi Yajie , Xing Yingqi , Wang Lijuan , Zhang Jie , Cao Yanting , Liu Li , Chen Ying 

TITLE=Multimodal Monitoring in Large Hemispheric Infarction: Quantitative Electroencephalography Combined With Transcranial Doppler for Prognosis Prediction

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.724571

DOI=10.3389/fneur.2021.724571

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> We aimed to explore whether transcranial Doppler (TCD) combined with quantitative electroencephalography (QEEG) can improve prognosis evaluation in patients with a large hemispheric infarction (LHI) and to establish an accurate prognosis prediction model.</p><p><bold>Methods:</bold> We prospectively assessed 90-day mortality in patients with LHI. Brain function was monitored using TCD-QEEG at the bedside of the patient.</p><p><bold>Results:</bold> Of the 59 (55.3 ± 10.6 years; 17 men) enrolled patients, 37 (67.3%) patients died within 90 days. The Cox regression analyses revealed that the Glasgow Coma Scale (GCS) score ≤ 8 [hazard ratio (HR), 3.228; 95% CI, 1.335–7.801; <italic>p</italic> = 0.009], TCD-terminal internal carotid artery as the offending vessel (HR, 3.830; 95% CI, 1.301–11.271; <italic>p</italic> = 0.015), and QEEG-a (delta + theta)/(alpha + beta) ratio ≥ 3 (HR, 3.647; 95% CI, 1.170–11.373; <italic>p</italic> = 0.026) independently predicted survival duration. Combining these three factors yielded an area under the receiver operating characteristic curve of 0.905 and had better predictive accuracy than those of individual variables (<italic>p</italic> &lt; 0.05).</p><p><bold>Conclusion:</bold> TCD and QEEG complement the GCS score to create a reliable multimodal method for monitoring prognosis in patients with LHI.</p>