AUTHOR=Laohathai Christopher , Ebersole John S. , Mosher John C. , Bagić Anto I. , Sumida Ai , Von Allmen Gretchen , Funke Michael E. 

TITLE=Practical Fundamentals of Clinical MEG Interpretation in Epilepsy

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.722986

DOI=10.3389/fneur.2021.722986

ISSN=1664-2295

ABSTRACT=<p>Magnetoencephalography (MEG) is a neurophysiologic test that offers a functional localization of epileptic sources in patients considered for epilepsy surgery. The understanding of clinical MEG concepts, and the interpretation of these clinical studies, are very involving processes that demand both clinical and procedural expertise. One of the major obstacles in acquiring necessary proficiency is the scarcity of fundamental clinical literature. To fill this knowledge gap, this review aims to explain the basic practical concepts of clinical MEG relevant to epilepsy with an emphasis on single equivalent dipole (sECD), which is one the most clinically validated and ubiquitously used source localization method, and illustrate and explain the regional topology and source dynamics relevant for clinical interpretation of MEG-EEG.</p>