AUTHOR=Verma Mansi , Tripathi Manjari , Nehra Ashima , Paplikar Avanthi , Varghese Feba , Alladi Suvarna , Narayanan Jwala , Dhaliwal R. S. , Sharma Meenakshi , Saroja Aralikatte Onkarappa , Arshad Faheem , Divyaraj Gollahalli , Ghosh Amitabha , Manae Tejaswini S. , Mekala Shailaja , Menon Ramshekhar N. , Hooda Roopa , Iyer Gowri K. , Sunitha J. , Kandukuri Rajmohan , Kaul Subhash , Khan Arfa Banu , Mathew Robert , Nandi Ranita , Padma M. V. , Pauranik Apoorva , Ramakrishnan Subasree , Sarath Lekha , Shah Urvashi , Sylaja P. N. , Varma Ravi Prasad , Vishwanath Yeshaswini 

TITLE=Validation of ICMR Neurocognitive Toolbox for Dementia in the Linguistically Diverse Context of India

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.661269

DOI=10.3389/fneur.2021.661269

ISSN=1664-2295

ABSTRACT=<p><bold>Objectives:</bold> The growing prevalence of dementia, especially in low- and middle-income countries (LMICs), has raised the need for a unified cognitive screening tool that can aid its early detection. The linguistically and educationally diverse population in India contributes to challenges in diagnosis. The present study aimed to assess the validity and diagnostic accuracy of the Indian Council of Medical Research-Neurocognitive Toolbox (ICMR-NCTB), a comprehensive neuropsychological test battery adapted in five languages, for the diagnosis of dementia.</p><p><bold>Methods:</bold> A multidisciplinary group of experts developed the ICMR-NCTB based on reviewing the existing tools and incorporation of culturally appropriate modifications. The finalized tests of the major cognitive domains of attention, executive functions, memory, language, and visuospatial skills were then adapted and translated into five Indian languages: Hindi, Bengali, Telugu, Kannada, and Malayalam. Three hundred fifty-four participants were recruited, including 222 controls and 132 dementia patients. The sensitivity and specificity of the adapted tests were established for the diagnosis of dementia.</p><p><bold>Results:</bold> A significant difference in the mean (median) performance scores between healthy controls and patients with dementia was observed on all tests of ICMR-NCTB. The area under the curve for majority of the tests included in the ICMR-NCTB ranged from 0.73 to 1.00, and the sensitivity and specificity of the ICMR-NCTB tests ranged from 70 to 100% and 70.7 to 100%, respectively, to identify dementia across all five languages.</p><p><bold>Conclusions:</bold> The ICMR-NCTB is a valid instrument to diagnose dementia across five Indian languages, with good diagnostic accuracy. The toolbox was effective in overcoming the challenge of linguistic diversity. The study has wide implications to address the problem of a high disease burden and low diagnostic rate of dementia in LMICs like India.</p>