AUTHOR=Liu Weibing , Yamamoto Tatsuya , Yamanaka Yoshitaka , Asahina Masato , Uchiyama Tomoyuki , Hirano Shigeki , Shimizu Keisuke , Higuchi Yoshinori , Kuwabara Satoshi 

TITLE=Neuropsychiatric Symptoms in Parkinson's Disease After Subthalamic Nucleus Deep Brain Stimulation

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.656041

DOI=10.3389/fneur.2021.656041

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> Indications for subthalamic nucleus deep brain stimulation (STN-DBS) surgery are determined basically by preoperative motor function; however, postoperative quality of life (QOL) is not necessarily associated with improvements in motor symptoms, suggesting that neuropsychiatric symptoms might be related to QOL after surgery in patients with Parkinson's disease.</p><p><bold>Objectives:</bold> We aimed to examine temporal changes in neuropsychiatric symptoms and their associations with QOL after STN-DBS.</p><p><bold>Materials and Methods:</bold> We prospectively enrolled a total of 61 patients with Parkinson's disease (mean age = 65.3 ± 0.9 years, mean disease duration = 11.9 ± 0.4 years). Motor function, cognitive function, and neuropsychiatric symptoms were evaluated before and after DBS surgery. Postoperative evaluation was performed at 3 months, 1 year, and 3 years after surgery.</p><p><bold>Results:</bold> Of the 61 participants, 54 completed postoperative clinical evaluation after 3 months, 47 after 1 year, and 23 after 3 years. Frontal lobe functions, depression, and verbal fluency significantly worsened 3 years after STN-DBS. Non-motor symptoms such as impulsivity and the Unified PD Rating Scale (UPDRS) part I score were associated with QOL after STN-DBS.</p><p><bold>Conclusions:</bold> Frontal lobe functions, depression, and verbal fluency significantly worsened 3 years after STN-DBS. The UPDRS part I score and higher impulsivity might be associated with QOL after STN-DBS.</p>