AUTHOR=Li Yunke , Wen Dingke , Cui Wenyao , Chen Yuqi , Zhang Fazhen , Yuan Maolin , Xiao Han , Li Hao , Ma Lu , Hu Xin , You Chao 

TITLE=The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.628557

DOI=10.3389/fneur.2021.628557

ISSN=1664-2295

ABSTRACT=<p><bold>Background and Purpose:</bold> The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH).</p><p><bold>Methods:</bold> Patients with primary spontaneous ICH were enrolled. SII was constructed based on peripheral platelet (P), neutrophil (N), and lymphocyte (L) and defined as P<sup>*</sup>N/L. In addition to admission testing, acute phase SII was collected to analyze the potential dynamic change. Poor outcome was defined as modified Rankin Scale of more than 3 at 90 days.</p><p><bold>Results:</bold> We included 291 patients; 98 (34%) achieved favorable functional outcomes. Day-1 SII was higher and was more related to poor outcome than was admission SII. Median time of day-1 SII was 29 h from onset. Day-1 SII had an OR in outcome (mRS &gt;3) 1.74 (95% CI = 1.03–3.00, <italic>p</italic> = 0.04). The binary cutoff point of SII calculated using the area under the curve (AUC) method was 1,700 × 10<sup>9</sup>/L, AUC 0.699 (95% CI = 0.627–0.774) (sensitivity 53.3%, specificity 77.3%) (OR = 2.36, 95% CI = 1.09–5.26, <italic>p</italic> = 0.03).</p><p><bold>Conclusions:</bold> SII, especially day-1 SII, was highly associated with 90-day functional outcome in patients with ICH and could be used to predict outcomes.</p>