AUTHOR=Li Mingming , Zhang Yue , Guan Yujia , Zhang Zunwei , Dong Hanbing , Zhao Yang , Deng Hui TITLE=A Case Report of Central Nervous System Graft-Versus-Host Disease and Literature Review JOURNAL=Frontiers in Neurology VOLUME=12 YEAR=2021 URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.621392 DOI=10.3389/fneur.2021.621392 ISSN=1664-2295 ABSTRACT=

As an adverse immune phenomenon, graft-versus-host disease often occurs after allogeneic hematopoietic stem cell transplantation. The incidence of acute and chronic graft-versus-host disease is about 40–60% and the mortality rate can reach 15%, which is a potentially fatal disease. There are rare GvHD cases involving the central nervous system. We reported a rare case of diffuse white matter changes after haploid bone marrow transplantation, summarizing its clinical manifestations and diagnosis and treatment in conjunction with the literature.