AUTHOR=Liu Lizhi , Gu Meifeng , Liu Jia , Liu Qing , Xu Xiaofeng , Fan Rong , Peng Fuhua , Jiang Ying 

TITLE=The Effect on the Kidney in Patients With Anti-N-methyl D-aspartate Receptor Antibody Encephalitis

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.601495

DOI=10.3389/fneur.2021.601495

ISSN=1664-2295

ABSTRACT=<p><bold>Objectives:</bold> The function of the N-methyl-D-aspartate receptor (NMDAR) in the kidney has been studied. However, the effect on the kidney from anti-NAMDAR antibody encephalitis has not been investigated thus far.</p><p><bold>Methods:</bold> Case data were collected from 82 patients with anti-NMDAR antibody encephalitis and 166 age- and sex-matched healthy controls (HCs). Clinical characteristics, urinalysis [including urine pH and urine specific gravity (SG)], serum creatinine (Scr), and estimated glomerular filtration rate (eGFR) based on Cr levels were evaluated.</p><p><bold>Results:</bold> At initial admission, urine pH levels and urine SG levels in anti-NMDAR antibody encephalitis patients were significantly higher and lower, respectively, than HCs (both <italic>p</italic> &lt; 0.001). There were no significant differences in Scr and eGFR between anti-NMDAR antibody encephalitis patients and HCs. Urine pH levels in patients with anti-NMDAR antibody &lt;1:32 were significantly lower than those in patients with anti-NMDAR antibody ≥1:32 (<italic>p</italic> = 0.029). Urine pH levels were significantly lower (<italic>p</italic> = 0.004) and urine SG levels were significantly higher (<italic>p</italic> = 0.027) in a follow-up evaluation 3 months after treatment.</p><p><bold>Conclusions:</bold> The changes in urinalysis occur in patients with anti-NMDAR antibody encephalitis. The pathophysiological changes in anti-NMDAR antibody encephalitis were not limited to the CNS.</p>