AUTHOR=Bai Jing , He Bing , Wang Nan , Chen Yifei , Liu Junxiang , Wang Haoran , Liu Dongliang 

TITLE=Snoring Is Associated With Increased Risk of Stroke: A Cumulative Meta-Analysis

JOURNAL=Frontiers in Neurology

VOLUME=12

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2021.574649

DOI=10.3389/fneur.2021.574649

ISSN=1664-2295

ABSTRACT=<p><bold>Background:</bold> Several studies have suggested that snoring is associated with an increased risk of stroke; however, the results are inconsistent. We aim to conduct a systematic review and meta-analysis of observational studies assessing the association between snoring and the risk of stroke in adults.</p><p><bold>Methods:</bold> We searched PubMed for relevant studies. A random-effect model was adopted to summary relative risks (RRs), and forest plots from a cumulative meta-analysis method were used for a better presentation of how the pooled RRs changed as updated evidence accumulated.</p><p><bold>Results:</bold> The literature search yielded 16 articles that met our inclusion criteria, and a total of 3,598 stroke patients and 145,901 participants were finally included in our analysis. A consistent trend toward association was found after the initial discovery, and the summary analysis indicated that snoring is associated with a 46% (RR, 1.46; 95%CI, 1.29–1.63; <italic>p</italic> &lt; 0.001) increased risk of stroke.</p><p><bold>Conclusions:</bold> Snoring is associated with a significantly increased risk for stroke, up to 46%. The importance of the current study lies in that we provide an imputes to take a more active approach against the increased risk of stroke in snorers.</p>