AUTHOR=Van Draanen Lauren , Xiao Changfu , Polymeropoulos Mihael H. 

TITLE=Estimating Burden of Disease Among Blind Individuals With Non-24-Hour Sleep-Wake Disorder

JOURNAL=Frontiers in Neurology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2020.605240

DOI=10.3389/fneur.2020.605240

ISSN=1664-2295

ABSTRACT=<p><bold>Purpose:</bold> To quantify the burden of disease in blind patients with Non-24-H Sleep- Wake Disorder (N24HSWD), utilizing longitudinal sleep diary data. N24HSWD is a circadian disorder characterized by a cyclical pattern of aberrant circadian and sleep-wake cycles that are associated with increased frequency of sleep episodes during the school/work day hours. Daytime sleep episodes would be predicted to decrease the opportunity for school/work participation, significantly impacting the quality of life of the patient.</p><p><bold>Methods:</bold> We used the sleep diary data of daytime sleep from a period of ~90 days in blind individuals that presented with a sleep complaint. These subjects were identified from a group of blind individuals with N24HSWD (<italic>n</italic> = 121) and a control group of blind individuals without N24HSWD (<italic>n</italic> = 57).</p><p><bold>Results:</bold> N24HSWD patients had more frequent and longer episodes of daytime sleep as compared to a control group. Using duration of daytime sleep as a surrogate for defining a healthy or unhealthy day, N24HSWD patients also had significantly fewer healthy days, defined by daytime sleep free days (DSFD), days without a sleep episode between 9:00 a.m. and 5:00 p.m, as compared to the control group.</p><p><bold>Conclusion:</bold> Daytime sleep free day (DSFD) is a useful and specific measure of disease burden in patients with N24HSWD and it is predicted to be correlated with the standardized HRQOL-4, Healthy Days measurement.</p>